Serum Proteomics Suggest Novel Mechanisms of Action of Semaglutide in Reducing the Risk of MACE in the SELECT Trial
by Prateek Chopra | July 5, 2026 | Diabetes Conferences | ADA 2026 Mechanistic Insights Methods Key Findings Protein-Specific Effects Clinical Implications Four circulating proteins—THBS2, NPPB, ANGPT2, and CD93—mediated a substantial proportion of semaglutide’s cardiovascular benefit independent of weight loss. These findings provide new insights into the biological mechanisms underlying semaglutide’s cardioprotective effects.