Effects of Empagliflozin on Hepatic Glucose Production, Gluconeogenesis, and Lipolysis in Type 2 Diabetes
by Prateek Chopra | June 26, 2026 | Diabetes Conferences | ADA 2026 Study Objective Methods Effects on Hepatic Glucose Metabolism Effects on Lipolysis Mechanistic Insights Clinical Implications Empagliflozin increased both gluconeogenesis and lipolysis in individuals with type 2 diabetes, with glycerol acting as an important gluconeogenic substrate. These compensatory metabolic responses help preserve hepatic glucose production and may explain