The Hypoglycemia Prevention Program (HPP) for Primary Care: Pilot Clinical Trial

by Prateek Chopra | June 22, 2026 | Diabetes Conferences | ADA 2026 | 0 comments

Clinical Need

  • Hypoglycemia remains a major cause of morbidity among people with diabetes, particularly those receiving insulin or sulfonylureas.
  • Despite its clinical importance, hypoglycemia is often underrecognized in primary care settings, and preventive strategies remain underutilized.

Program Overview

  • The Hypoglycemia Prevention Program (HPP) was evaluated as an EHR-integrated toolkit designed to improve hypoglycemia prevention in primary care.
  • The pilot study enrolled adults with diabetes treated with insulin or sulfonylureas.

Intervention Components

  • Patient Hypoglycemia Profile completed through the EHR before clinic visits.
  • Provider Hypoglycemia Toolkit with EHR alerts and management recommendations.
  • Patient education handout focused on hypoglycemia prevention.

Patient Participation

  • Thirty-five participants were enrolled.
  • Thirty-one participants (88.6%) completed the intervention.

Key Findings

  • The HPP demonstrated high patient acceptability and low perceived burden.
  • Glucagon prescribing increased significantly from 0% at baseline to 29% following implementation (p=0.004).
  • Favorable trends toward reductions in hypoglycemia-related outcomes were observed, although statistical significance was not achieved.

Clinical Implications

  • EHR-based tools may facilitate early identification of individuals at high risk for hypoglycemia.
  • Integration of risk assessment and management strategies into routine care may improve hypoglycemia prevention practices.

The EHR-integrated HPP was well accepted by patients and improved hypoglycemia prevention practices in primary care. Further studies are warranted to determine its long-term impact on reducing hypoglycemic events.

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